take care和take care of的区别有：1、意思不同：take care意思是：保重，注意(一般是跟别人道别的时候用)。take care of意思是：照顾，护理。2、用法不同：take care of后面要接名词，不可单独使用。take care可单独使用，后面不需要接成分。
take care造句示例：1、Take care! There's a car coming towards you.当心，有辆车朝你开来了!2、Take care not to let these goods be rained on!当心别让这些货物被雨水淋湿了!3、Take care (that) you don't drink too much/not to drink too much.当心别喝多了。4、He is in a bad temper this morning; take care not to step on his toes.他今天上午心情不好，当心一点，不要触犯他。
take care of造句示例：1、Take care of yourselves.你们自己照顾自己吧.2、Please take care of everything.以后请多关照.3、Take care of your health.关注你自己的健康.4、Have you is take care of?有人招呼您了吗?
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